Hyunsu Lee | NeuroAI Lab

Diagnosis classification in EMR data using latent representations and SNOMED-CT mapping for improved medical data integration

Mon, 10 Aug 2026 00:00:00 +0000

CASCADE: criticality avalanche spike cross-platform analysis detection engine, a multi-manufacturer MEA bash analysis pipeline

Mon, 03 Aug 2026 00:00:00 +0000

Evaluation of the Anti-Cancer Effects of KMU-11342 in In Vitro and Ex Vivo Models of Colorectal Cancer

Thu, 25 Jun 2026 00:00:00 +0000

ACh-modulated predecessor feature learning enables post-reward exploration

Fri, 05 Jun 2026 00:00:00 +0000

Our paper, “Eligibility-trace–gated depression in predecessor feature learning enables post-reward exploration,” has been published.

In this study, we propose an acetylcholine (ACh)-modulated predecessor feature learning model and investigate how it can support flexible exploration even after reward acquisition.

Using n-arm radial maze simulations, we found that the conventional PF model showed clear limitations under post-reward exploration conditions, whereas the ACh-PF model substantially improved exploration performance within an appropriate range of modulation strength. However, this effective range became narrower as the environment became more complex.

The paper is available here:
https://rdcu.be/fmrWK

Intuitive Risk Equation for Post-Transplant Bloodstream Infection Prediction: A Symbolic Regression Approach

Tue, 07 Apr 2026 00:00:00 +0000

A novel small molecule KMU-11361 attenuates rheumatoid arthritis by mechanistic inhibition of the TAK1–NF-κB–NLRP3 axis

Tue, 17 Mar 2026 00:00:00 +0000

End-to-End EEG-Based Stress Detection: A Benchmark Using Repurposed DEAP and Russell’s Circumplex Model

Thu, 01 Jan 2026 00:00:00 +0000

Cell-Free Supernatant of Vaginal Viridans Streptococcus Induces Membrane Permeabilization and Transcriptional Regulation in Methicillin-Resistant Staphylococcus aureus

Mon, 01 Dec 2025 00:00:00 +0000

Pangenome analysis of Lactobacillus mulieris strains reveals distinct subspecies clusters with defined ecological adaptations

Tue, 04 Nov 2025 00:00:00 +0000

Characterization of Streptococcus mitis subsp. carlssonii isolated from human vagina: prevalence, phenotypic, and genomic insights

Mon, 25 Aug 2025 00:00:00 +0000

In silico discovery of novel compounds for FAK activation using virtual screening, AI-based prediction, and molecular dynamics

Fri, 01 Aug 2025 00:00:00 +0000

Editorial: Hippocampal function and reinforcement learning

Tue, 08 Apr 2025 00:00:00 +0000

Noise Resilience of Successor and Predecessor Feature Algorithms in One- and Two-Dimensional Environments has been published.

Fri, 07 Feb 2025 00:00:00 +0000

Lee H. Noise Resilience of Successor and Predecessor Feature Algorithms in One- and Two-Dimensional Environments. Sensors. 2025; 25(3):979. https://doi.org/10.3390/s25030979

We compared the ability of SF and PF, reinforcement learning algorithms associated with the hippocampus of the brain, to reliably navigate noisy environments.

Noise Resilience of Successor and Predecessor Feature Algorithms in One- and Two-Dimensional Environments

Thu, 06 Feb 2025 00:00:00 +0000

Immune cell-enriched single-cell RNA sequencing unveils the interplay between infiltrated CD8+ T resident memory cells and choroid plexus epithelial cells in Alzheimer's disease

Wed, 01 Jan 2025 00:00:00 +0000

Supernumerary Head of the Biceps Brachii Muscle Influences the Topography of the Coracobrachialis and Biceps Brachii Muscles

Tue, 22 Oct 2024 00:00:00 +0000

Our Latest Research on Transfer Learning in Noisy Environments Published!

Fri, 04 Oct 2024 00:00:00 +0000

We’re excited to share that our study, “Investigating Transfer Learning in Noisy Environments: A Study of Predecessor and Successor Features in Spatial Learning Using a T-Maze,” has been published in Sensors!

In this study, we delve into the critical challenge of noise in reinforcement learning environments. Specifically, we focus on how transfer learning algorithms—Predecessor and Successor Features (PFs and SFs)—perform in spatial learning tasks under noisy conditions.

Why Is This Study Important?

Noise is a significant factor in real-world applications, especially for systems that rely on accurate sensor data to make decisions. Our study provides valuable insights into how learning models can be optimized in such conditions by fine-tuning hyperparameters like the reward learning rate and eligibility trace decay. We discovered that these parameters significantly influence the agent’s adaptability and learning efficiency, providing practical guidelines for improving the performance of sensor-driven systems in noisy, dynamic environments.

Key Takeaways from Our Study:

We evaluated the impact of various hyperparameters on adaptive behavior in noisy spatial learning environments using a T-maze, revealing their critical role in learning efficiency.
We introduced a framework based on PF and SF to compare and quantify sensitivity to noise and adaptation in reinforcement learning models.
We identified the most robust hyperparameter configurations that optimize performance in noisy and variable conditions, providing practical insights for improving system adaptability.

This research offers valuable contributions to the fields of sensor systems, robotics, and autonomous navigation by enhancing learning models’ resilience to noise.

Read the full paper here to learn more! Additionally, the code used in the study can be accessed here.

Investigating Transfer Learning in Noisy Environments: A Study of Predecessor and Successor Features in Spatial Learning Using a T-Maze

Thu, 03 Oct 2024 00:00:00 +0000

Net synaptic drive of fast-spiking interneurons is inverted towards inhibition in human FCD I epilepsy

Tue, 06 Aug 2024 00:00:00 +0000

The rise of ChatGPT : Exploring its potential in medical education

Mon, 01 Jul 2024 00:00:00 +0000

The Neuroprotective Effect of Therapeutic Hypothermia in Cognitive Impairment of an Ischemia/Reperfusion Injury Mouse Model

Tue, 20 Feb 2024 00:00:00 +0000

SungSu Oh has joined our lab!

Mon, 05 Feb 2024 00:00:00 +0000

He plans to enroll in the first semester of 2024 and study medical artificial intelligence and predictive model development using machine learning and deep learning.

Reflections on the Development of Large Language Models and Their Impact on Basic Medical Education

Mon, 01 Jan 2024 00:00:00 +0000

Deokhyeon Yoon has joined our lab!!

Sun, 10 Dec 2023 00:00:00 +0000

He is going to dig into drug discovery using machine learning.

Zulip Cloud Standard plan sponsorship approved.

Thu, 07 Dec 2023 00:00:00 +0000

We are pleased to announce that Zulip Cloud Standard plan sponsorship has been approved.

Zulip is a messaging app for work and collaboration like Slack, Teamchat. It is maintained as an open-source project.

Our lab’s Zulip is https://neuroai.zulipchat.com/ .

Tuning the Weights: The Impact of Initial Matrix Configurations on Successor Features’ Learning Efficacy

Wed, 11 Oct 2023 00:00:00 +0000

An Image Turing Test on Realistic Gastroscopy Images Generated by Using the Progressive Growing of Generative Adversarial Networks

Mon, 13 Mar 2023 00:00:00 +0000

Bioinformatic analysis of the obesity paradox and possible associated factors in colorectal cancer using TCGA cohorts

Sun, 01 Jan 2023 00:00:00 +0000

The Value of Anatomy in Medical Humanities Education for Future Talents

Sun, 01 Jan 2023 00:00:00 +0000

Toward the biological model of the hippocampus as the successor representation agent

Tue, 01 Mar 2022 00:00:00 +0000

A Simple Method to Locate the Master Knot of Henry Using the Correlation between the Flexor Tendon Length Parameter and the Foot Length

Thu, 17 Feb 2022 00:00:00 +0000

Clinical Value of EZH2 in Hepatocellular Carcinoma and Its Potential for Target Therapy

Thu, 20 Jan 2022 00:00:00 +0000

A Critical Review on the Argument that the Sacral Division of the Autonomic Nervous System should be Classified as the Sympathetic Nervous System

Sat, 01 Jan 2022 00:00:00 +0000

My new paper just disclosed in preprint arXiv server.

Thu, 04 Nov 2021 00:00:00 +0000

Preprint for “The effect of synaptic weight initialization in feature-based successor representation learning” was just disclosed.

This paper explores the learning efficiency according to the weight initialization method in feature-based SR learning and discusses from neurobiological perspectives.

Machine learning approach for differentiating cytomegalovirus esophagitis from herpes simplex virus esophagitis

Thu, 11 Feb 2021 00:00:00 +0000

Topography and Anatomical Variations of the Axillary Artery

Fri, 01 Jan 2021 00:00:00 +0000

My new paper just disclosed.

Tue, 25 Aug 2020 00:00:00 +0000

I just published my paper at arXiv.

I’m happy to finish my paper.

This is the link for my paper.

I already posted about the result of the paper as conference poster in my blog, check this.

Neuromatch 2.0 poster

Wed, 20 May 2020 00:00:00 +0000

[pdf-embedder url=“neuromatch_slideposter.pdf”]

Depression and Anxiety Disorder in Perspective of Neurogenesis and Pattern Separation

Wed, 01 Jan 2020 00:00:00 +0000

Predicting transgenic markers of a neuron by electrophysiological properties using machine learning

Thu, 01 Aug 2019 00:00:00 +0000

Different correlations between tumor size and cancer-related gene profiles according to histologic type of salivary gland tumor

Tue, 01 Jan 2019 00:00:00 +0000

Effectiveness of Smartphone Application in Histology Practice

Tue, 01 Jan 2019 00:00:00 +0000

TERT Promoter Mutation and Telomere Length in Salivary Gland Tumors

Sun, 01 Jul 2018 00:00:00 +0000

Loss of the Association between Telomere Length and Mitochondrial DNA Copy Number Contribute to Colorectal Carcinogenesis

Sun, 01 Apr 2018 00:00:00 +0000

Three Dimensional Nucleus Imaging analysis & in vitro Genotoxicity Test through Advanced Cytokinesis-Block Micronucleus Assay

Mon, 01 Jan 2018 00:00:00 +0000

Topography of the Middle Genicular Artery is Associated with the Superior and Inferior Genicular Arteries

Fri, 01 Sep 2017 00:00:00 +0000

Mutation of the TERT promoter leads to poor prognosis of patients with non-small cell lung cancer

Tue, 01 Aug 2017 00:00:00 +0000

Topographical relations between the Gantzer’s muscle and neurovascular structures

Tue, 01 Aug 2017 00:00:00 +0000

A multi-scale model for hair follicles reveals heterogeneous domains driving rapid spatiotemporal hair growth patterning

Tue, 11 Jul 2017 00:00:00 +0000

Comparison of the Electrophysiological Properties of Excitatory and Inhibitory Neurons in the Mouse Visual Cortex

Mon, 01 May 2017 00:00:00 +0000

Absence of GNAS Mutation in Colorectal Carcinogenesis

Wed, 01 Mar 2017 00:00:00 +0000

Double Gantzer's Muscles by Four Muscle Bellies and Its Clinical Significance: A Case Report

Sun, 01 Jan 2017 00:00:00 +0000

The Application and Effectiveness for Medical Procedural Skills through the Use of the Cadaver Model

Sun, 01 Jan 2017 00:00:00 +0000

Topography of the coracobrachialis muscle and the musculocutaneous nerve by muscular variation

Sun, 01 Jan 2017 00:00:00 +0000

A radial artery originating from the thoracoacromial artery

Fri, 01 Jul 2016 00:00:00 +0000

Muscular axillary arch accompanying variation of the musculocutaneous nerve: axillary arch

Fri, 01 Jan 2016 00:00:00 +0000

TERT promoter mutation, telomere length, and TERT expression in gastric cancer

Fri, 01 Jan 2016 00:00:00 +0000

Bidirectional Signaling of Neuregulin-2 Mediates Formation of GABAergic Synapses and Maturation of Glutamatergic Synapses in Newborn Granule Cells of Postnatal Hippocampus

Wed, 16 Dec 2015 00:00:00 +0000

The ileocolic vein passing through the ring-shaped part of ileocolic artery

Thu, 01 Oct 2015 00:00:00 +0000

Are PIK3CA Mutation and Amplification Associated with Clinicopathological Characteristics of Gastric Cancer?

Fri, 26 Jun 2015 00:00:00 +0000

Low frequency of the lateral thoracic artery originating from the thoracoacromial artery

Wed, 01 Apr 2015 00:00:00 +0000

Is Mitochondrial DNA Copy Number Associated with Clinical Characteristics and Prognosis in Gastric Cancer?

Wed, 04 Feb 2015 00:00:00 +0000

PIK3CA Amplification Is Common in Left Side-Tubular Adenomas but Uncommon Sessile Serrated Adenomas Exclusively with KRAS Mutation

Thu, 01 Jan 2015 00:00:00 +0000

Reply: Anomalous Muscles in Carpal Tunnel Associated with Neurovascular Variation: Case Report and Brief Review

Thu, 01 Jan 2015 00:00:00 +0000

Variations of the cubital superficial vein investigated by using the intravenous illuminator

Thu, 01 Jan 2015 00:00:00 +0000

Improved application of the electrophoretic tissue clearing technology, CLARITY, to intact solid organs including brain, pancreas, liver, kidney, lung, and intestine

Mon, 01 Dec 2014 00:00:00 +0000

Leptin promotes K ATP channel trafficking by AMPK signaling in pancreatic β-cells

Tue, 30 Jul 2013 00:00:00 +0000

GABA mediates the network activity‐dependent facilitation of axonal outgrowth from the newborn granule cells in the early postnatal rat hippocampus

Sat, 01 Sep 2012 00:00:00 +0000

Prolonged Membrane Depolarization Enhances Midbrain Dopamine Neuron Differentiation via Epigenetic Histone Modifications

Tue, 01 Nov 2011 00:00:00 +0000

Protein-based human iPS cells efficiently generate functional dopamine neurons and can treat a rat model of Parkinson disease

Wed, 01 Jun 2011 00:00:00 +0000